Patrick Thomas led Irondequoit with 17 points as the Eagles beat Wayne for the third straight time, and the second consecutive Class A State Qualifier game, 69-41.
Gerald Drumgoole and Josh Stenglein scored 12 points each and Robert Diaz-Judson added 10.
Nick Carmichael led Wayne with 13 points.
Irondequoit beat Wayne in the Class A playoff last season at Bloomfield and the won a regular season game between the teams as well.
The defending NYS Class A Champions face West Seneca West in the West Regionals at Buffalo State at 7:00 Saturday.