The Buffalo Bills will be missing at least one of their key players on Sunday against the Indianapolis Colts.

Head coach Sean McDermott says that rookie wide receiver Keon Coleman will be out for Sunday’s game. Coleman has a wrist injury that could cause him to miss multiple games.

Fellow wide receiver Amari Cooper, who missed last week’s game with a wrist injury, was limited in practice Friday and will be listed as questionable to play against the Colts.

That means reserve players from the practice squad could be called upon to contribute this weekend.

"Trust those players. Trust the guys in our locker room, the guys at those positions like we’ve done before," McDermott said. "Those guys have done a really good job of stepping up and stepping in and we’ll need more of it as we move forward here."

The Bills are looking for their fifth straight win on Sunday while trying to improve their record to 8-2 for the first time since 1992.