All northbound and southbound lanes between exits 8 and 9 on the I-190 will be closed Saturday night for the installation of the Ralph Wilson Park Bridge.
The lanes are slated to close starting at 9 p.m. and will reopen on Sunday at 10 a.m.
Motorists are asked to avoid the area if possible.
Ralph Wilson Park will also be closed during that timeframe.
The new 266-foot pedestrian bridge will allow people to walk, run or bike from the city's West Side over the 190 to the park.
The park's $110 million transformation is slated to be complete in 2026.