PHILADELPHIA — Marcus Mariota made his debut at quarterback for the Philadelphia Eagles on Sunday when Jalen Hurts was checked for a concussion and briefly left the game against San Francisco in the fourth quarter, returning after a visit to the locker room.

The 49ers went on to win 42-19.

Hurts was 17-of-29 passing for 196 yards and scored a rushing touchdown before he was forced out late in the game. Hurts, last season's NFL MVP runner-up, jogged off the field in the fourth and went straight to the locker room.

Mariota, a Saint Louis School graduate and nine-year NFL veteran who has played for the Tennessee Titans, Las Vegas Raiders and Atlanta Falcons, was 2-for-3 passing for 16 yards and carried the ball twice for 6 yards.

After Mariota took over, San Francisco scored on the next drive for a 35-13 lead.

Hurts returned to the sideline during the Eagles' next possession and replaced Mariota mid-drive with about nine minutes left. He marched Philadelphia into the red zone and completed a 2-yard TD to DeVonta Smith.

Hurts had led the Eagles to an NFL best 10-1 record headed into Sunday. He had been 27-2 over his last 29 regular-season starts.