Back in 2007, then-Tioga County District Attorney Gerald Keene thought the trial of Cal Harris was over.
"The tremendous amount of evidence of motive and his controlling behavior and certainly all the blood evidence. I didn't think there was any other explanation," Keene said after hearing the verdict.
The trial of the Owego businessman rocked the small community where Harris had lived with his estranged wife, Michele, and their four young children before she disappeared on September 11, 2001.
Harris was convicted of Michele's murder not once, but twice, despite the lack of a murder weapon or 35-year-old Michele Harris' body.
"Cal did not commit this crime. An innocent man has been wrongfully convicted," said defense attorney Terence Kindlon in 2009.
"When he said 'I have a place to put you where you're not going to be found,' he meant it. And that's where she is and she's not going to be found," Keene said in 2007.
A surprise 11th hour witness in 2007 and procedural errors in 2009 ended with both convictions thrown out and a third trial set to begin this week.
"We're heartened we have a new trial." said defense attorney Bill Easton after the announcement in 2012. "The court of appeals recognized that the first trial was not fair."
Ahead of the latest trial, now moved more than 100 miles away to Schoharie County, Harris made national news. He avowed his innocence on the CBS show 48 hours.
"Three times now I've had to sit in a jail cell or prison cell and wait for the court of appeals to overturn this thing," Harris said in the interview.
And in a press conference in March, Cal appeared with his children as they asked the public for information that would exonerate their father.
"We need to know what really happened to our mother," said Michele Harris' oldest daughter Cayla.
Now with a third defense team, and a new prosecutor, another 12 jurors will soon decide Harris' fate.
Jury selection is set to begin on Thursday.