ORCHARD PARK, N.Y. -- Buffalo Bills running back Karlos Williams will be sitting out the first four games of the 2016 NFL season.

The NFL informed the Bills Williams violated the NFL Policy and Program for Substances of Abuse. He'll be able to return to the roster on Monday, Oct. 3 following the teams Oct. 2 game against the New England Patriots, which QB Tom Brady will be sitting out.

Williams is, however, eligible to participate in all offseason and preseason games and practices. 

“As an organization, we are disappointed that Karlos has put himself in this situation. Poor decisions such as this affect not only the individual, but the entire Bills organization. We will continue to work with Karlos through the various player programs we provide to assist him in making better decisions moving forward," the team said in a statement.

Williams was in line to once again be the club's No. 2 running back this season behind starter LeSean McCoy.  However, he showed up to the offseason program overweight and out of shape following the birth of his child.

Williams burst onto the scene as a rookie last season, rushing for 517 yards and nine total touchdowns.