The response has been the same all week by Bills players and coaches alike.

"You can't replace Tre White."

But that's exactly what this team has to do with White out for the remainder of this season with a torn ACL.

Under the "next man up" mantra, Dane Jackson will slide into White's starting role.

"He just needs to be Dane Jackson and not Tre'Davious White," head coach Sean McDermott said.

"We're not asking him to be All-Pro and shutdown every single receiver and follow the best receivers and do all that type of stuff," safety Micah Hyde added. "We just asking him to do his job and everyone else on the defensive side just step your role up a little bit more."

"We tell him all the time he's not out there alone," safety Jordan Poyer said. "He ain't got to go out there and do nothing other than be Dane Jackson."

But Jackson understands the magnitude of what's ahead of him.

"It's a huge opportunity," Jackson said. "I've been telling myself since it happened, this is an opportunity of a lifetime. This is what I've been dreaming of. This is what I've been working for. Obviously I didn't want it to happen the way it happened, but this is my once in a lifetime opportunity so I'm ready to take advantage of it."

Jackson has been in this position before, elevating from the practice squad to play in five games with two starts last season as a rookie.

He flashed in limited work, grabbing an interception with 5 pass break-ups and a fumble recovery. That level of play pushed Jackson into a training camp competition with Levi Wallace for the starting CB job opposite White, but Wallace ultimately held onto his job.

The second year player feels he has used that experience to make him better.

"The biggest thing I learned was obviously there's more work to be done," Jackson said. "Maybe I wasn't ready for that position. Maybe the man above wasn't ready to put me in that position. There's just a lot of work to be done. I got a lot of areas I could improve on and when that happened I worked on those areas so I make sure that it won't happen again."

One person helping Jackson prepare for his elevated role is the man he's sliding in for, White.

"I've been talking to him every single day," Jackson said. "He's been telling me tips. Stuff I was seeing on film, I'd go to him and he'd tell me the same thing which would make me feel more comfortable. All-Pro corner, he's watching film and I'm seeing the same thing."

Monday Night Football will be the first chance we get to see how different the Bills are with Dane Jackson.