The Bills are one of three teams in the NFL who are averaging under 300 yards of total offense a game (Titans 262.7, Bills 222.5, and Cardinals 220.7). They are joined by Arizona as the only teams to fail to eclipse 300 yards of total offense in a single game this season. However, the Bills are the only team failing to rip off an average of four yards per play, sitting at just 3.69.

All that really adds up to the number that matters most when it comes to wins and losses — points, and the Bills are last in the NFL in that as well with a measly 12.7.

LeSean McCoy admitted this week that the offense feels like they are letting the defense down. Good news for this week is that the Colts defense ranks in the lower third in the league in yards and points allowed per game. Let's dive into how these two match-up:

From the Beach to Bills Starter

​Derek Anderson was chasing his kids around on vacation two weeks ago. He signed with the Bills last Tuesday to be a mentor to Josh Allen. Now he is this team's starting quarterback. 

Anderson last completed a pass Week 3 of last season. He last started a game in 2016, where his last touchdown pass was week four. The last time Anderson won a game he started was all the way back on December 14th, 2014. So it is not only that he hasn't been with the Bills even two weeks, it is that he hasn't had any real extended game action in four years. 

The biggest challenge at hand is for Anderson to learn the playbook. He says that if he cannot visualize the play by Sunday, he will tell Brian Daboll it cannot be used against the Colts. 

Sean McDermott says practice has been altered a little this week to help Anderson get up to speed quicker and Anderson himself has called for extra work to be done after practice and in the film room.

Find the Benjamin Blanket

Kelvin Benjamin has been an incredible disappointment so far this season. For the supposed number one target to have just ten catches for 146 yards and a touchdown through six games is unacceptable. But could Anderson's arrival spark better production from Benjamin?

The two played together in Carolina, with Anderson throwing Benjamin his first career touchdown pass in his first career NFL game in 2014. In six games together, Benjamin had 23 receptions for 336 yards and two TDs courtesy of Anderson. Benjamin said this week he feels at ease with Anderson and it is undeniable that their previous history working together should help — and maybe steer more targets Benjamin's way.

Stick With the Run​

I pointed out last week the discrepancy between the Bills run/pass ratio in wins and losses this year, with the ground game being called upon nearly twice as much as the passing in the two victories, as opposed to much more pass-happy play-calling in defeats. The split was nearly even against the Texans, so a change to the trend in a loss. I think things should tilt back in favor of the running game, especially as a way to take some of the pressure off of Anderson and his need to make reads. This will not be easy because of all the things the Colts defense struggles at, stopping the run is the one area they have done well, ranking fourth in the NFL in rushing yards per play at just 3.75.

Feeling Lucky

​Andrew Luck is averaging 48 pass attempts per game this season. At that pace, he will set the NFL record with 768 attempts. I am not sure he is 100 percent back to the quarterback he was before injuries kept him off the field nearly two years, but he is still slinging it well. What is interesting is for all the passing he is doing, the Colts offensive line is keeping him upright most of the time. Luck's only been sacked 10 times this season, getting sacked just 3.46% of the time, third best in the NFL. The Bills are tied for 5th in the NFL in sacks with 19 at a rate of 8.96%, which ranks 8th. It's a battle of strength versus strength and with Indy having one of the worst rushing attacks in the league, the Bills should be able to pin their ears back and play the pass.

​Giveaway/Takeaway

Now this is a strength for the Bills against a major weakness for the Colts. The Bills have forced 12 takeaways, 11 of which have come in the past four games. The defense feels that number should be even higher after only recovering seven of the 13 fumbles they've forced. On the flip side, Indianapolis has given the ball away 13 times and overall sport a -3 differential. If the turnover train can keep rolling at against the Colts the Bills could once again be in line for a win.

Bills and Colts kick things off Sunday from Lucas Oil Stadium in Indianapolis at 1 p.m.