Aquinas and McQuaid, a pair of longtime Section Five rivals squared off in the Frontier Field Kickoff Classic, where McQuaid was looking to beat the Irish for the first time since 2006.
Frontier Field, the home of Red Wings baseball hosted its first ever football game.
Aquinas gets on the board first when Tyler Szalkowski rolls out and finds Ulysees Russell in the endzone to make it 7-0. The Knights answer in the second quarter, Joe Cairns to Jordan Brongo and it's 7-7 at the break.
McQuaid grabbed momentum in the second-half thanks to a pair of touchdowns from Andrew Passero to help them build a 27-7 lead.
Aquinas battles back and when Szalkowski throws a TD pass to Zach Kelsey, they cut the deficit to 27-21.
But the Knights are able to run out the clock and their losing streak to Aquinas comes to an end, 27-21 the final. The Annual Challenge Trophy between the two schools goes to McQuaid.