The calls are reported in various ways--intoxicated persons, ambulance calls, unconscious persons and a few other categories.

What they can mean?

Each can be a person overdosing on synthetic marijuana. 

"Syracuse seems to be being hit the most. And it's definitely been in the last week or so that we've had this increase in this area."

This week in Syracuse-area hospitals, there have been reports of more patients with symptoms of synthetic marijuana use. The Upstate New York Poison Center has only had a few cases in the last week. 

Clinical Toxicologist Jeanna Marraffa says local hospitals have seen more than 20 cases in the last 48 hours. Doctors at Crouse Health say they've seen much more than usual overdoses in the ER, presumably relating to synthetic marijuana or "Spike."

"It tends to be consistently from May to July where we see more cases. We had a very similar increase in cases this time last year," said Marraffa.

"What we're seeing with a lot of our overdose patients is that some will have very fast heart rates and others will have very slow heart rates," said Nicolas Corbishley AMR Operations Supervisor.

Syracuse police say they have not identified a brand leading to the increased overdoses, or if it's something else altogether. At AMR they say they've had more than 40 calls this week.

At least two dozen were called in on Wednesday.

"There are really two sub-sections of patients. The first of which is very docile and we can pretty much get them to the ambulance without any issue and they're very calm for most of the transport. The other end of the spectrum are the patients that are very violent and aggressive towards us," said Corbishley.

Like a similar trend three years ago, the calls are coming from all over the city, according to Corbishley. In 2015, the trend lasted roughly a few weeks.

"The biggest issue is that there is so much different spike being sold and passed around that it's hard to determine what's actually in there and the side-effects are going to differ depending on which pack you're taking," said Corbishley.

Marraffa says there is a strain of synthetic marijuana that contains chemicals that are found in rat poison. She says those that take it are known to bleed from the mouth and gums. Although that strain hasn't made it to the Central New York area, she says local hospitals are on high alert.