As the losses start to pile up for the Bills, so do the injuries.

The running game has struggled all season and now LeSean McCoy is day-to-day with a hamstring issue and his backup Chris Ivory has a shoulder problem.

Defensively, linebacker Matt Milano is done for the final three weeks after surgery for a broken leg. Lorenzo Alexander, Deon Lacey and Corey Thompson are among those who could fill in for the Milano, who was having a standout second year.

”Having a Pro Bowl-caliber season, so you hate to see him injured and being out for the rest of the season,” said Bills defensive coordinator Leslie Frazier. “Would’ve really liked to see how he finished the year. He was putting up some really good numbers, and hopefully he’ll be back in the offseason and be able to go through a full offseason program along with training camp.

Josh Allen took a few hits but he walked away with just some soreness. The rookie quarterback continues to rack up the rushing yards: he’s now the team's leading runner after another 100 yard performance.

But the question remains — how much is too much for Allen running instead of throwing.

”I think it’s probably honestly going to be an ongoing conversation. Josh is a mobile quarterback. Mobile quarterbacks… there’s a conversation about them every week,” said Bills head coach Sean McDermott. “‘Are they running too much? Are they not running enough? What happened to the quarterback run?’ So at the end of the day, we have to keep Josh upright. He took some hits yesterday that he can’t take and we’ve got to make sure we do a good job of protecting him. But Josh has to help himself out at times in being smart with the football, and the alarm clock in his mind has to go off, as well, in getting rid of the ball and living to play another down.”

As for the rest of the rushing attack outside of Allen, McCoy and company have failed to get going all season.  Asked what can be done to get the ground game going, McDermott said it starts up front.