CHARLOTTE, N.C. — American Airlines has canceled its daily Germany flights to and from Charlotte-Douglas International Airport, effective Friday, as the airline evaluates its worldwide network of routes amid the coronavirus pandemic.

Federal travel restrictions going into effect Friday will likely cause major issues for Charlotte-area businesses.

About 57,000 people in the Charlotte region earn their paycheck working for the roughly 700 European companies with a presence in the area, according to the Charlotte Regional Business Alliance.

Many rely on the 35 plus direct international flights through Charlotte-Douglas, including daily flights to Munich and Frankfurt.

“We have in the surroundings of only 50 miles, we have 213 German companies,” German honorary consul Klaus Becker said. “These are not Mickey Mouse companies. These are companies of fine, advanced manufacturing. Where people like to go, love the job, and make good money there.”

American Airlines has already announced it’s cutting domestic flights 7.5 percent in April, network wide. International flights will decrease 10 percent during the Summer peak. It’s not clear how else those changes will impact Charlotte.

The airline had already cenceled flights to Italy