The eastbound lanes of the Thruway are back open Wednesday morning between the Westfield and Dunkirk-Fredonia exits.
State Police say one person died in a multi-vehicle crash just after 7 p.m. Tuesday.
Eastbound traffic was diverted off the Thruway at exit 61 while crews worked to clear the scene.
All lanes reopened around 2 a.m. Wednesday.
Troopers are still looking into what caused the crash.