The Bills have led the NFL in rushing in each of LeSean McCoy's first two seasons in Buffalo, with the running back coming off one of the best years of his career. With the offense now seemingly less equipped with other weapons than before, McCoy's going to have to carry even more of the team's fortunes.

"Whatever it takes to win the game. That’s how we play the game," said Sean McDermott. "We play to win, and whatever it takes to win the game, that’s what we’re going to do. If it means he’s got to play every snap, that’s what we’ll do. If he’s feeling good, like it is for every player, I’m going to look them in the eye, say ‘how do you feel? Feel good? Alright, let’s go."

"Whatever it takes. If it’s on the ground or in the air, it may be a key block, whatever it takes to win, I’m down for it," McCoy said. "Since I’ve been here, we’ve had a lot of talent, we just have to get over that point, as far as winning and getting to the playoffs.​"

Richie Incognito said his offensive line is ready and willing to run the ball as much as possible, and says McCoy "looks great. He's dynamic. He's making cuts. He's a game-changer. He's a homerun hitter, and I'm really glad he's on our team."