Dylan Rice and Othman Belhseine had two goals and an assist each as seventh seeded Athena defeated Wilson 7-3.
The Trojans advance to the Class A quarterfinals to meet number 2 Spencerport, a 2-0 winner over defending champion Brockport.
In other games, Class Double-A, defending champion McQuaid was knocked out by number seven Penfield and third-seeded Fairport fell to Rush-Henrietta.
In Class A, fifth seeded Greece Arcadia was upset by 12th seeded Irondequoit.